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The ubiquitin ligase c-CBL is expressed in undifferentiated marmoset monkey pluripotent stem cells but is not a general stem cell marker

The protein c-CBL is a ubiquitin ligase. It catalyzes the last step of the transfer of ubiquitin to target proteins. Upon completion of polyubiquitination, the target proteins are degraded. Clinically, it is important that c-CBL is mutated in a subset of patients who develop myeloid malignancies, wh...

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Detalles Bibliográficos
Autores principales: Rodriguez-Polo, Ignacio, Nielsen, Maike, Debowski, Katharina, Behr, Rüdiger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Copernicus GmbH 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041541/
https://www.ncbi.nlm.nih.gov/pubmed/32110709
http://dx.doi.org/10.5194/pb-4-231-2017