Halogenation of the N‐Terminus Tyrosine 10 Promotes Supramolecular Stabilization of the Amyloid‐β Sequence 7–12

Here, we demonstrate that introduction of halogen atoms at the tyrosine 10 phenol ring of the DSGYEV sequence derived from the flexible amyloid‐β N‐terminus, promotes its self‐assembly in the solid state. In particular, we report the crystal structures of two halogen‐modified sequences, which we fou...

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Detalles Bibliográficos
Autores principales: Maiolo, Daniele, Pizzi, Andrea, Gori, Alessandro, Gazzera, Lara, Demitri, Nicola, Genoni, Alessandro, Baggi, Fulvio, Moda, Fabio, Terraneo, Giancarlo, Baldelli Bombelli, Francesca, Metrangolo, Pierangelo, Resnati, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041548/
https://www.ncbi.nlm.nih.gov/pubmed/32110506
http://dx.doi.org/10.1002/open.201900350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041548/
https://www.ncbi.nlm.nih.gov/pubmed/32110506
http://dx.doi.org/10.1002/open.201900350

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