IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress. When modeled in HEK293 cells and with purified protein, IRE1β diminishes expression...

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Detalles Bibliográficos
Autores principales: Grey, Michael J., Cloots, Eva, Simpson, Mariska S., LeDuc, Nicole, Serebrenik, Yevgeniy V., De Luca, Heidi, De Sutter, Delphine, Luong, Phi, Thiagarajah, Jay R., Paton, Adrienne W., Paton, James C., Seeliger, Markus A., Eyckerman, Sven, Janssens, Sophie, Lencer, Wayne I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041686/
https://www.ncbi.nlm.nih.gov/pubmed/31985747
http://dx.doi.org/10.1083/jcb.201904048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041686/
https://www.ncbi.nlm.nih.gov/pubmed/31985747
http://dx.doi.org/10.1083/jcb.201904048

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