GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch

The GABA response switch from excitatory to inhibitory is a key event in neuronal maturation that depends on the regulated expression of chloride transporters NKCC1 and KCC2. In this issue, Lee et al. (2020. J. Cell. Biol. https://doi.org/10.1083/jcb.201903033) describe how degradation of NKCC1 by p...

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Detalles Bibliográficos
Autor principal: Leterrier, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041697/
https://www.ncbi.nlm.nih.gov/pubmed/31930378
http://dx.doi.org/10.1083/jcb.201912006
Descripción
Sumario:The GABA response switch from excitatory to inhibitory is a key event in neuronal maturation that depends on the regulated expression of chloride transporters NKCC1 and KCC2. In this issue, Lee et al. (2020. J. Cell. Biol. https://doi.org/10.1083/jcb.201903033) describe how degradation of NKCC1 by proteasomes immobilized at the axon initial segment (AIS) by the Ecm29 adaptor contributes to this regulation, driving the GABA switch and the positional maturation of the AIS.

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