GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch

The GABA response switch from excitatory to inhibitory is a key event in neuronal maturation that depends on the regulated expression of chloride transporters NKCC1 and KCC2. In this issue, Lee et al. (2020. J. Cell. Biol. https://doi.org/10.1083/jcb.201903033) describe how degradation of NKCC1 by p...

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Detalles Bibliográficos
Autor principal: Leterrier, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041697/
https://www.ncbi.nlm.nih.gov/pubmed/31930378
http://dx.doi.org/10.1083/jcb.201912006
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author Leterrier, Christophe
author_facet Leterrier, Christophe
author_sort Leterrier, Christophe
collection PubMed
description The GABA response switch from excitatory to inhibitory is a key event in neuronal maturation that depends on the regulated expression of chloride transporters NKCC1 and KCC2. In this issue, Lee et al. (2020. J. Cell. Biol. https://doi.org/10.1083/jcb.201903033) describe how degradation of NKCC1 by proteasomes immobilized at the axon initial segment (AIS) by the Ecm29 adaptor contributes to this regulation, driving the GABA switch and the positional maturation of the AIS.
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spelling pubmed-70416972020-08-03 GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch Leterrier, Christophe J Cell Biol Spotlight The GABA response switch from excitatory to inhibitory is a key event in neuronal maturation that depends on the regulated expression of chloride transporters NKCC1 and KCC2. In this issue, Lee et al. (2020. J. Cell. Biol. https://doi.org/10.1083/jcb.201903033) describe how degradation of NKCC1 by proteasomes immobilized at the axon initial segment (AIS) by the Ecm29 adaptor contributes to this regulation, driving the GABA switch and the positional maturation of the AIS. Rockefeller University Press 2020-01-13 /pmc/articles/PMC7041697/ /pubmed/31930378 http://dx.doi.org/10.1083/jcb.201912006 Text en © 2020 Leterrier http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Leterrier, Christophe
GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch
title GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch
title_full GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch
title_fullStr GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch
title_full_unstemmed GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch
title_short GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch
title_sort gaba in, garbage out: ais-located proteasomes regulate the developmental gaba switch
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041697/
https://www.ncbi.nlm.nih.gov/pubmed/31930378
http://dx.doi.org/10.1083/jcb.201912006
work_keys_str_mv AT leterrierchristophe gabaingarbageoutaislocatedproteasomesregulatethedevelopmentalgabaswitch

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