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Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2

Uric acid is a common metabolite found in mammals’ serum. Recently, several metabolites have been identified that modulate aging, and uric acid levels are positively correlated with mammals’ lifespan. However, the molecular mechanisms underlying this are largely undefined. Here we show that uric aci...

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Detalles Bibliográficos
Autores principales: Wan, Qin-Li, Fu, Xiaodie, Dai, Wenyu, Yang, Jing, Luo, Zhenhuan, Meng, Xiao, Liu, Xiao, Zhong, Ruowei, Yang, Hengwen, Zhou, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041755/
https://www.ncbi.nlm.nih.gov/pubmed/32074508
http://dx.doi.org/10.18632/aging.102781