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CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice

As the elderly population grows, chronic metabolic dysfunction including obesity and diabetes are becoming increasingly common comorbidities. Hypothalamic inflammation through CNS resident microglia serves as a common pathway between developing obesity and developing systemic aging pathologies. Desp...

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Detalles Bibliográficos
Autores principales: Ali, Seemaab, Mansour, Anthony G., Huang, Wei, Queen, Nicholas J., Mo, Xiaokui, Anderson, Jacqueline M., Hassan II, Quais N., Patel, Ripal S., Wilkins, Ryan K., Caligiuri, Michael A., Cao, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041757/
https://www.ncbi.nlm.nih.gov/pubmed/32007953
http://dx.doi.org/10.18632/aging.102724