High expression of SMYD3 indicates poor survival outcome and promotes tumour progression through an IGF-1R/AKT/E2F-1 positive feedback loop in bladder cancer

The AKT/mTOR pathway is critical for bladder cancer (BC) pathogenesis and is hyper-activated during BC progression. In the present study, we identified a novel positive feedback loop involving oncogenic factors histone methyltransferase SMYD3, insulin-like growth factor-1 receptor (IGF-1R), AKT, and...

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Detalles Bibliográficos
Autores principales: Wang, Guoliang, Huang, Yi, Yang, Feilong, Tian, Xiaojun, Wang, Kun, Liu, Li, Fan, Yidong, Li, Xiaofeng, Li, Luchao, Shi, Benkang, Hao, Yichang, Xia, Chuanyou, Nie, Qingsheng, Xin, Yue, Shi, Zhenfeng, Ma, Lulin, Xu, Dawei, Liu, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041758/
https://www.ncbi.nlm.nih.gov/pubmed/32007952
http://dx.doi.org/10.18632/aging.102718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041758/
https://www.ncbi.nlm.nih.gov/pubmed/32007952
http://dx.doi.org/10.18632/aging.102718

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