Insulin impedes osteogenesis of BMSCs by inhibiting autophagy and promoting premature senescence via the TGF-β1 pathway

The dysfunction of bone marrow stromal cells (BMSCs) may be a core factor in Type 2 diabetes mellitus (T2DM) associated osteoporosis. However, the underlying mechanism is not well understood. Here, we delineated the critical role of insulin impeding osteogenesis of BMSCs in T2DM. Compared with BMSCs...

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Detalles Bibliográficos
Autores principales: Zhang, Ping, Zhang, Hengguo, Lin, Jialin, Xiao, Tao, Xu, Rongyao, Fu, Yu, Zhang, Yuchao, Du, Yifei, Cheng, Jie, Jiang, Hongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041775/
https://www.ncbi.nlm.nih.gov/pubmed/32017705
http://dx.doi.org/10.18632/aging.102723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041775/
https://www.ncbi.nlm.nih.gov/pubmed/32017705
http://dx.doi.org/10.18632/aging.102723

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