Adaptive landscape flattening allows the design of both enzyme: Substrate binding and catalytic power

Designed enzymes are of fundamental and technological interest. Experimental directed evolution still has significant limitations, and computational approaches are a complementary route. A designed enzyme should satisfy multiple criteria: stability, substrate binding, transition state binding. Such...

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Detalles Bibliográficos
Autores principales: Opuu, Vaitea, Nigro, Giuliano, Gaillard, Thomas, Schmitt, Emmanuelle, Mechulam, Yves, Simonson, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041857/
https://www.ncbi.nlm.nih.gov/pubmed/31917825
http://dx.doi.org/10.1371/journal.pcbi.1007600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041857/
https://www.ncbi.nlm.nih.gov/pubmed/31917825
http://dx.doi.org/10.1371/journal.pcbi.1007600

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