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Adaptive landscape flattening allows the design of both enzyme: Substrate binding and catalytic power
Designed enzymes are of fundamental and technological interest. Experimental directed evolution still has significant limitations, and computational approaches are a complementary route. A designed enzyme should satisfy multiple criteria: stability, substrate binding, transition state binding. Such...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041857/ https://www.ncbi.nlm.nih.gov/pubmed/31917825 http://dx.doi.org/10.1371/journal.pcbi.1007600 |