Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis

Force generation by actin assembly shapes cellular membranes. An experimentally constrained multiscale model shows that a minimal branched actin network is sufficient to internalize endocytic pits against membrane tension. Around 200 activated Arp2/3 complexes are required for robust internalization...

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Detalles Bibliográficos
Autores principales: Akamatsu, Matthew, Vasan, Ritvik, Serwas, Daniel, Ferrin, Michael A, Rangamani, Padmini, Drubin, David G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041948/
https://www.ncbi.nlm.nih.gov/pubmed/31951196
http://dx.doi.org/10.7554/eLife.49840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041948/
https://www.ncbi.nlm.nih.gov/pubmed/31951196
http://dx.doi.org/10.7554/eLife.49840

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