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Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis
Force generation by actin assembly shapes cellular membranes. An experimentally constrained multiscale model shows that a minimal branched actin network is sufficient to internalize endocytic pits against membrane tension. Around 200 activated Arp2/3 complexes are required for robust internalization...
Autores principales: | Akamatsu, Matthew, Vasan, Ritvik, Serwas, Daniel, Ferrin, Michael A, Rangamani, Padmini, Drubin, David G |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041948/ https://www.ncbi.nlm.nih.gov/pubmed/31951196 http://dx.doi.org/10.7554/eLife.49840 |
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