Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells

Ribosome stalling triggers the ribosome-associated quality control (RQC) pathway, which targets collided ribosomes and leads to subunit dissociation, followed by proteasomal degradation of the nascent peptide. In yeast, RQC is triggered by Hel2-dependent ubiquitination of uS10, followed by subunit d...

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Detalles Bibliográficos
Autores principales: Hashimoto, Satoshi, Sugiyama, Takato, Yamazaki, Reina, Nobuta, Risa, Inada, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042231/
https://www.ncbi.nlm.nih.gov/pubmed/32099016
http://dx.doi.org/10.1038/s41598-020-60241-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042231/
https://www.ncbi.nlm.nih.gov/pubmed/32099016
http://dx.doi.org/10.1038/s41598-020-60241-w

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