Dual-molecular barcode sequencing detects rare variants in tumor and cell free DNA in plasma

Conventional next generation sequencing analysis has provided important insights into cancer genetics. However, the detection of rare (low allele fraction) variants remains difficult because of the error-prone nucleotide changes derived from sequencing/PCR errors. To eliminate the false-positive var...

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Detalles Bibliográficos
Autores principales: Hirotsu, Yosuke, Otake, Sotaro, Ohyama, Hiroshi, Amemiya, Kenji, Higuchi, Rumi, Oyama, Toshio, Mochizuki, Hitoshi, Goto, Taichiro, Omata, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042261/
https://www.ncbi.nlm.nih.gov/pubmed/32099048
http://dx.doi.org/10.1038/s41598-020-60361-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042261/
https://www.ncbi.nlm.nih.gov/pubmed/32099048
http://dx.doi.org/10.1038/s41598-020-60361-3

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