Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction

Insulin resistance increases patients’ risk of developing type 2 diabetes (T2D), non-alcoholic steatohepatitis (NASH) and a host of other comorbidities including cardiovascular disease and cancer. At the molecular level, insulin exerts its function through the insulin receptor (IR), a transmembrane...

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Detalles Bibliográficos
Autores principales: Ding, Xunshan, Iyer, Rugmani, Novotny, Christopher, Metzger, Daniel, Zhou, Heather H., Smith, Gordon I., Yoshino, Mihoko, Yoshino, Jun, Klein, Samuel, Swaminath, Gayathri, Talukdar, Saswata, Zhou, Yingjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042267/
https://www.ncbi.nlm.nih.gov/pubmed/32099031
http://dx.doi.org/10.1038/s41598-020-60290-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042267/
https://www.ncbi.nlm.nih.gov/pubmed/32099031
http://dx.doi.org/10.1038/s41598-020-60290-1

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