Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates

Accurate quantification of synaptic changes is essential for understanding the molecular mechanisms of synaptogenesis, synaptic plasticity, and synaptic toxicity. Here we demonstrate a robust high-content imaging method for the assessment of synaptic changes and apply the method to brain homogenates...

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Detalles Bibliográficos
Autores principales: Jiang, Hao, Esparza, Thomas J., Kummer, Terrance T., Zhong, Haining, Rettig, Jens, Brody, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042280/
https://www.ncbi.nlm.nih.gov/pubmed/32098978
http://dx.doi.org/10.1038/s41598-020-60118-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042280/
https://www.ncbi.nlm.nih.gov/pubmed/32098978
http://dx.doi.org/10.1038/s41598-020-60118-y

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