Measuring single cell divisions in human tissues from multi-region sequencing data

Both normal tissue development and cancer growth are driven by a branching process of cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. However, quantifying somatic evolution in humans remains challenging. Here, we show that multi-sample genomic data from a si...

Descripción completa

Detalles Bibliográficos
Autores principales: Werner, Benjamin, Case, Jack, Williams, Marc J., Chkhaidze, Ketevan, Temko, Daniel, Fernández-Mateos, Javier, Cresswell, George D., Nichol, Daniel, Cross, William, Spiteri, Inmaculada, Huang, Weini, Tomlinson, Ian P. M., Barnes, Chris P., Graham, Trevor A., Sottoriva, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042311/
https://www.ncbi.nlm.nih.gov/pubmed/32098957
http://dx.doi.org/10.1038/s41467-020-14844-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042311/
https://www.ncbi.nlm.nih.gov/pubmed/32098957
http://dx.doi.org/10.1038/s41467-020-14844-6

Ejemplares similares