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Orthologous promoters from related methylotrophic yeasts surpass expression of endogenous promoters of Pichia pastoris

Methylotrophic yeasts such as Komagataella phaffii (syn. Pichia pastoris, Pp), Hansenula polymorpha (Hp), Candida boidinii (Cb) and Pichia methanolica (Pm) are widely used protein production platforms. Typically, strong, tightly regulated promoters of genes coding for their methanol utilization (MUT...

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Detalles Bibliográficos
Autores principales: Vogl, Thomas, Fischer, Jasmin Elgin, Hyden, Patrick, Wasmayer, Richard, Sturmberger, Lukas, Glieder, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042429/
https://www.ncbi.nlm.nih.gov/pubmed/32100120
http://dx.doi.org/10.1186/s13568-020-00972-1