Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system

In this study, we show that the percutaneous absorption and brain distribution of tetramethylpyrazine (TMP) is enhanced when combined with borneol (BN) in a microemulsion-based transdermal therapeutic system (ME-TTS). The formulation of the TMP and BN microemulsion (TEM-BN-ME) was optimized in skin...

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Autores principales: Hu, Xiaoge, Cheng, Ning, Zhao, Jihui, Piao, Xianghua, Yan, Yulu, Zhang, Qibo, Zhou, Kuan, Zhang, Yongtai, Feng, Nianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042483/
https://www.ncbi.nlm.nih.gov/pubmed/32104460
http://dx.doi.org/10.1016/j.ajps.2018.06.003
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author Hu, Xiaoge
Cheng, Ning
Zhao, Jihui
Piao, Xianghua
Yan, Yulu
Zhang, Qibo
Zhou, Kuan
Zhang, Yongtai
Feng, Nianping
author_facet Hu, Xiaoge
Cheng, Ning
Zhao, Jihui
Piao, Xianghua
Yan, Yulu
Zhang, Qibo
Zhou, Kuan
Zhang, Yongtai
Feng, Nianping
author_sort Hu, Xiaoge
collection PubMed
description In this study, we show that the percutaneous absorption and brain distribution of tetramethylpyrazine (TMP) is enhanced when combined with borneol (BN) in a microemulsion-based transdermal therapeutic system (ME-TTS). The formulation of the TMP and BN microemulsion (TEM-BN-ME) was optimized in skin permeation studies in vitro following a uniform experimental design. Male Sprague-Dawley rats were used for the in vivo pharmacokinetic and tissue distribution studies of TMP-BN-ME-TTS. In the pharmacokinetic study, the TMP-BN-ME-TTS treated rats had significantly higher (P < 0.05) C(max) and AUC of TMP than the TMP-ME-TTS treated rats, indicating that BN improves the rate and extent of TMP percutaneous absorption. In the tissue distribution study, the AUC of TMP in brain was significantly higher in the TMP-BN-ME-TTS group (P < 0.05), indicating that BN facilitates the distribution of TMP in brain. In summary, BN enhanced the percutaneous absorption and brain distribution of TMP in a microemulsion-based transdermal therapeutic system.
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spelling pubmed-70424832020-02-26 Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system Hu, Xiaoge Cheng, Ning Zhao, Jihui Piao, Xianghua Yan, Yulu Zhang, Qibo Zhou, Kuan Zhang, Yongtai Feng, Nianping Asian J Pharm Sci Research Article In this study, we show that the percutaneous absorption and brain distribution of tetramethylpyrazine (TMP) is enhanced when combined with borneol (BN) in a microemulsion-based transdermal therapeutic system (ME-TTS). The formulation of the TMP and BN microemulsion (TEM-BN-ME) was optimized in skin permeation studies in vitro following a uniform experimental design. Male Sprague-Dawley rats were used for the in vivo pharmacokinetic and tissue distribution studies of TMP-BN-ME-TTS. In the pharmacokinetic study, the TMP-BN-ME-TTS treated rats had significantly higher (P < 0.05) C(max) and AUC of TMP than the TMP-ME-TTS treated rats, indicating that BN improves the rate and extent of TMP percutaneous absorption. In the tissue distribution study, the AUC of TMP in brain was significantly higher in the TMP-BN-ME-TTS group (P < 0.05), indicating that BN facilitates the distribution of TMP in brain. In summary, BN enhanced the percutaneous absorption and brain distribution of TMP in a microemulsion-based transdermal therapeutic system. Shenyang Pharmaceutical University 2019-05 2018-07-29 /pmc/articles/PMC7042483/ /pubmed/32104460 http://dx.doi.org/10.1016/j.ajps.2018.06.003 Text en © 2018 Shenyang Pharmaceutical University. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Hu, Xiaoge
Cheng, Ning
Zhao, Jihui
Piao, Xianghua
Yan, Yulu
Zhang, Qibo
Zhou, Kuan
Zhang, Yongtai
Feng, Nianping
Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system
title Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system
title_full Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system
title_fullStr Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system
title_full_unstemmed Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system
title_short Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system
title_sort percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042483/
https://www.ncbi.nlm.nih.gov/pubmed/32104460
http://dx.doi.org/10.1016/j.ajps.2018.06.003
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