Entropic Bristles Tune the Seeding Efficiency of Prion-Nucleating Fragments

Prions of lower eukaryotes are self-templating protein aggregates with cores formed by parallel in-register beta strands. Short aggregation-prone glutamine (Q)- and asparagine (N)-rich regions embedded in longer disordered domains have been proposed to act as nucleation sites that initiate refolding...

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Detalles Bibliográficos
Autores principales: Michiels, Emiel, Liu, Shu, Gallardo, Rodrigo, Louros, Nikolaos, Mathelié-Guinlet, Marion, Dufrêne, Yves, Schymkowitz, Joost, Vorberg, Ina, Rousseau, Frederic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043027/
https://www.ncbi.nlm.nih.gov/pubmed/32101755
http://dx.doi.org/10.1016/j.celrep.2020.01.098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043027/
https://www.ncbi.nlm.nih.gov/pubmed/32101755
http://dx.doi.org/10.1016/j.celrep.2020.01.098

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