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Entropic Bristles Tune the Seeding Efficiency of Prion-Nucleating Fragments
Prions of lower eukaryotes are self-templating protein aggregates with cores formed by parallel in-register beta strands. Short aggregation-prone glutamine (Q)- and asparagine (N)-rich regions embedded in longer disordered domains have been proposed to act as nucleation sites that initiate refolding...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043027/ https://www.ncbi.nlm.nih.gov/pubmed/32101755 http://dx.doi.org/10.1016/j.celrep.2020.01.098 |