Current understanding of the human microbiome

Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in the throughput and accuracy of DNA sequencing of the genomes of microbial communities associated with human samples, comp...

Descripción completa

Detalles Bibliográficos
Autores principales: Gilbert, Jack, Blaser, Martin J., Caporaso, J. Gregory, Jansson, Janet, Lynch, Susan V., Knight, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043356/
https://www.ncbi.nlm.nih.gov/pubmed/29634682
http://dx.doi.org/10.1038/nm.4517
_version_ 1783501432165498880
author Gilbert, Jack
Blaser, Martin J.
Caporaso, J. Gregory
Jansson, Janet
Lynch, Susan V.
Knight, Rob
author_facet Gilbert, Jack
Blaser, Martin J.
Caporaso, J. Gregory
Jansson, Janet
Lynch, Susan V.
Knight, Rob
author_sort Gilbert, Jack
collection PubMed
description Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in the throughput and accuracy of DNA sequencing of the genomes of microbial communities associated with human samples, complemented by analysis of transcriptomes, proteomes, metabolomes and immunomes, and mechanistic experiments in model systems, have vastly improved our ability to understand the structure and function of the microbiome in both diseased and healthy states. However, many challenges remain. In this Review, we focus on studies in humans to describe these challenges, and propose strategies that leverage existing knowledge to move rapidly from correlation to causation, and ultimately to translation.
format Online
Article
Text
id pubmed-7043356
institution National Center for Biotechnology Information
language English
publishDate 2018
record_format MEDLINE/PubMed
spelling pubmed-70433562020-02-26 Current understanding of the human microbiome Gilbert, Jack Blaser, Martin J. Caporaso, J. Gregory Jansson, Janet Lynch, Susan V. Knight, Rob Nat Med Article Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in the throughput and accuracy of DNA sequencing of the genomes of microbial communities associated with human samples, complemented by analysis of transcriptomes, proteomes, metabolomes and immunomes, and mechanistic experiments in model systems, have vastly improved our ability to understand the structure and function of the microbiome in both diseased and healthy states. However, many challenges remain. In this Review, we focus on studies in humans to describe these challenges, and propose strategies that leverage existing knowledge to move rapidly from correlation to causation, and ultimately to translation. 2018-04-10 /pmc/articles/PMC7043356/ /pubmed/29634682 http://dx.doi.org/10.1038/nm.4517 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Gilbert, Jack
Blaser, Martin J.
Caporaso, J. Gregory
Jansson, Janet
Lynch, Susan V.
Knight, Rob
Current understanding of the human microbiome
title Current understanding of the human microbiome
title_full Current understanding of the human microbiome
title_fullStr Current understanding of the human microbiome
title_full_unstemmed Current understanding of the human microbiome
title_short Current understanding of the human microbiome
title_sort current understanding of the human microbiome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043356/
https://www.ncbi.nlm.nih.gov/pubmed/29634682
http://dx.doi.org/10.1038/nm.4517
work_keys_str_mv AT gilbertjack currentunderstandingofthehumanmicrobiome
AT blasermartinj currentunderstandingofthehumanmicrobiome
AT caporasojgregory currentunderstandingofthehumanmicrobiome
AT janssonjanet currentunderstandingofthehumanmicrobiome
AT lynchsusanv currentunderstandingofthehumanmicrobiome
AT knightrob currentunderstandingofthehumanmicrobiome