Current understanding of the human microbiome
Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in the throughput and accuracy of DNA sequencing of the genomes of microbial communities associated with human samples, comp...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043356/ https://www.ncbi.nlm.nih.gov/pubmed/29634682 http://dx.doi.org/10.1038/nm.4517 |
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author | Gilbert, Jack Blaser, Martin J. Caporaso, J. Gregory Jansson, Janet Lynch, Susan V. Knight, Rob |
author_facet | Gilbert, Jack Blaser, Martin J. Caporaso, J. Gregory Jansson, Janet Lynch, Susan V. Knight, Rob |
author_sort | Gilbert, Jack |
collection | PubMed |
description | Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in the throughput and accuracy of DNA sequencing of the genomes of microbial communities associated with human samples, complemented by analysis of transcriptomes, proteomes, metabolomes and immunomes, and mechanistic experiments in model systems, have vastly improved our ability to understand the structure and function of the microbiome in both diseased and healthy states. However, many challenges remain. In this Review, we focus on studies in humans to describe these challenges, and propose strategies that leverage existing knowledge to move rapidly from correlation to causation, and ultimately to translation. |
format | Online Article Text |
id | pubmed-7043356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
record_format | MEDLINE/PubMed |
spelling | pubmed-70433562020-02-26 Current understanding of the human microbiome Gilbert, Jack Blaser, Martin J. Caporaso, J. Gregory Jansson, Janet Lynch, Susan V. Knight, Rob Nat Med Article Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in the throughput and accuracy of DNA sequencing of the genomes of microbial communities associated with human samples, complemented by analysis of transcriptomes, proteomes, metabolomes and immunomes, and mechanistic experiments in model systems, have vastly improved our ability to understand the structure and function of the microbiome in both diseased and healthy states. However, many challenges remain. In this Review, we focus on studies in humans to describe these challenges, and propose strategies that leverage existing knowledge to move rapidly from correlation to causation, and ultimately to translation. 2018-04-10 /pmc/articles/PMC7043356/ /pubmed/29634682 http://dx.doi.org/10.1038/nm.4517 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Gilbert, Jack Blaser, Martin J. Caporaso, J. Gregory Jansson, Janet Lynch, Susan V. Knight, Rob Current understanding of the human microbiome |
title | Current understanding of the human microbiome |
title_full | Current understanding of the human microbiome |
title_fullStr | Current understanding of the human microbiome |
title_full_unstemmed | Current understanding of the human microbiome |
title_short | Current understanding of the human microbiome |
title_sort | current understanding of the human microbiome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043356/ https://www.ncbi.nlm.nih.gov/pubmed/29634682 http://dx.doi.org/10.1038/nm.4517 |
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