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Scale‐down studies for the scale‐up of a recombinant Corynebacterium glutamicum fed‐batch fermentation: loss of homogeneity leads to lower levels of cadaverine production
BACKGROUND: The loss of efficiency and performance of bioprocesses on scale‐up is well known, but not fully understood. This work addresses this problem, by studying the effect of some fermentation gradients (pH, glucose and oxygen) that occur at the larger scale in a bench‐scale two‐compartment rea...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043379/ https://www.ncbi.nlm.nih.gov/pubmed/32139953 http://dx.doi.org/10.1002/jctb.6248 |