Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing

Voltage-gated sodium channels play a critical role in cellular excitability, amplifying small membrane depolarizations into action potentials. Interactions with auxiliary subunits and other factors modify the intrinsic kinetic mechanism to result in new molecular and cellular functionality. We show...

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Detalles Bibliográficos
Autores principales: Navarro, Marco A, Salari, Autoosa, Lin, Jenna L, Cowan, Luke M, Penington, Nicholas J, Milescu, Mirela, Milescu, Lorin S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043890/
https://www.ncbi.nlm.nih.gov/pubmed/32101161
http://dx.doi.org/10.7554/eLife.54940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043890/
https://www.ncbi.nlm.nih.gov/pubmed/32101161
http://dx.doi.org/10.7554/eLife.54940

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