Analysis of unusual and signature APOBEC-mutations in HIV-1 pol next-generation sequences

INTRODUCTION: At low mutation-detection thresholds, next generation sequencing (NGS) for HIV-1 genotypic resistance testing is susceptible to artifactual detection of mutations arising from PCR error and APOBEC-mediated G-to-A hypermutation. METHODS: We analyzed published HIV-1 pol Illumina NGS data...

Descripción completa

Detalles Bibliográficos
Autores principales: Tzou, Philip L., Kosakovsky Pond, Sergei L., Avila-Rios, Santiago, Holmes, Susan P., Kantor, Rami, Shafer, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043932/
https://www.ncbi.nlm.nih.gov/pubmed/32102090
http://dx.doi.org/10.1371/journal.pone.0225352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043932/
https://www.ncbi.nlm.nih.gov/pubmed/32102090
http://dx.doi.org/10.1371/journal.pone.0225352

Ejemplares similares