Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation

High YAP activity is associated with poor prognosis human breast cancers, but its role during the initial stage of mammary cell transformation is unknown. To address this question, we designed experiments that exploit the ability of KRAS(G12D)-transduced subsets of freshly isolated normal human mamm...

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Detalles Bibliográficos
Autores principales: Lefort, Sylvain, Tan, Susanna, Balani, Sneha, Rafn, Bo, Pellacani, Davide, Hirst, Martin, Sorensen, Poul H., Eaves, Connie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044112/
https://www.ncbi.nlm.nih.gov/pubmed/31772328
http://dx.doi.org/10.1038/s41388-019-1111-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044112/
https://www.ncbi.nlm.nih.gov/pubmed/31772328
http://dx.doi.org/10.1038/s41388-019-1111-0

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