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Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation
High YAP activity is associated with poor prognosis human breast cancers, but its role during the initial stage of mammary cell transformation is unknown. To address this question, we designed experiments that exploit the ability of KRAS(G12D)-transduced subsets of freshly isolated normal human mamm...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044112/ https://www.ncbi.nlm.nih.gov/pubmed/31772328 http://dx.doi.org/10.1038/s41388-019-1111-0 |