Power and pitfalls of computational methods for inferring clone phylogenies and mutation orders from bulk sequencing data

Tumors harbor extensive genetic heterogeneity in the form of distinct clone genotypes that arise over time and across different tissues and regions in cancer. Many computational methods produce clone phylogenies from population bulk sequencing data collected from multiple tumor samples from a patien...

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Detalles Bibliográficos
Autores principales: Miura, Sayaka, Vu, Tracy, Deng, Jiamin, Buturla, Tiffany, Oladeinde, Olumide, Choi, Jiyeong, Kumar, Sudhir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044161/
https://www.ncbi.nlm.nih.gov/pubmed/32103044
http://dx.doi.org/10.1038/s41598-020-59006-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044161/
https://www.ncbi.nlm.nih.gov/pubmed/32103044
http://dx.doi.org/10.1038/s41598-020-59006-2

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