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Power and pitfalls of computational methods for inferring clone phylogenies and mutation orders from bulk sequencing data
Tumors harbor extensive genetic heterogeneity in the form of distinct clone genotypes that arise over time and across different tissues and regions in cancer. Many computational methods produce clone phylogenies from population bulk sequencing data collected from multiple tumor samples from a patien...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044161/ https://www.ncbi.nlm.nih.gov/pubmed/32103044 http://dx.doi.org/10.1038/s41598-020-59006-2 |