In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson’s Disease in Common Marmosets

Leucine-rich repeat kinase 2 (LRRK2) G2019S is a relatively common mutation, associated with 1–3% of Parkinson’s disease (PD) cases worldwide. G2019S is hypothesized to increase LRRK2 kinase activity. Dopaminergic neurons derived from induced pluripotent stem cells of PD patients carrying LRRK2 G201...

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Detalles Bibliográficos
Autores principales: Vermilyea, Scott C., Babinski, Alexander, Tran, Nina, To, Samantha, Guthrie, Scott, Kluss, Jillian H., Schmidt, Jenna Kropp, Wiepz, Gregory J., Meyer, Michael G., Murphy, Megan E., Cookson, Mark R., Emborg, Marina E., Golos, Thaddeus G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044232/
https://www.ncbi.nlm.nih.gov/pubmed/32103062
http://dx.doi.org/10.1038/s41598-020-60273-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044232/
https://www.ncbi.nlm.nih.gov/pubmed/32103062
http://dx.doi.org/10.1038/s41598-020-60273-2

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