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Spatial modeling of prostate cancer metabolic gene expression reveals extensive heterogeneity and selective vulnerabilities
Spatial heterogeneity is a fundamental feature of the tumor microenvironment (TME), and tackling spatial heterogeneity in neoplastic metabolic aberrations is critical for tumor treatment. Genome-scale metabolic network models have been used successfully to simulate cancer metabolic networks. However...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044328/ https://www.ncbi.nlm.nih.gov/pubmed/32103057 http://dx.doi.org/10.1038/s41598-020-60384-w |