A proposed reverse transcription mechanism for (CAG)n and similar expandable repeats that cause neurological and other diseases

The mechanism of (CAG)n repeat generation, and related expandable repeat diseases in non-dividing cells, is currently understood in terms of a DNA template-based DNA repair synthesis process involving hairpin stabilized slippage, local error-prone repair via MutSβ (MSH2–MSH3) hairpin protective stab...

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Detalles Bibliográficos
Autores principales: Franklin, Andrew, Steele, Edward J., Lindley, Robyn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044655/
https://www.ncbi.nlm.nih.gov/pubmed/32140575
http://dx.doi.org/10.1016/j.heliyon.2020.e03258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044655/
https://www.ncbi.nlm.nih.gov/pubmed/32140575
http://dx.doi.org/10.1016/j.heliyon.2020.e03258

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