Factors Impacting Efficacy of AAV-Mediated CRISPR-Based Genome Editing for Treatment of Choroidal Neovascularization

Frequent injections of anti-vascular endothelial growth factor (anti-VEGF) agents are a clinical burden for patients with neovascular age-related macular degeneration (AMD). Genomic disruption of VEGF-A using adeno-associated viral (AAV) delivery of clustered regularly interspaced short palindromic...

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Detalles Bibliográficos
Autores principales: Chung, Sook Hyun, Mollhoff, Iris Natalie, Nguyen, Uyen, Nguyen, Amy, Stucka, Natalie, Tieu, Eric, Manna, Suman, Meleppat, Ratheesh Kumar, Zhang, Pengfei, Nguyen, Emerald Lovece, Fong, Jared, Zawadzki, Robert, Yiu, Glenn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044682/
https://www.ncbi.nlm.nih.gov/pubmed/32128346
http://dx.doi.org/10.1016/j.omtm.2020.01.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044682/
https://www.ncbi.nlm.nih.gov/pubmed/32128346
http://dx.doi.org/10.1016/j.omtm.2020.01.006

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