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CBX4 transcriptionally suppresses KLF6 via interaction with HDAC1 to exert oncogenic activities in clear cell renal cell carcinoma

BACKGROUND: Dysregulation of polycomb chromobox (CBX) proteins that mediate epigenetic gene silencing contributes to the progression of human cancers. Yet their roles in clear cell renal cell carcinoma (ccRCC) remain to be explored. METHODS: The expression of CBX4 and its clinical significance were...

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Detalles Bibliográficos
Autores principales: Jiang, Nan, Niu, Gang, Pan, Ying-Hua, Pan, Wenwei, Zhang, Mei-Fang, Zhang, Chris Zhiyi, Shen, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044754/
https://www.ncbi.nlm.nih.gov/pubmed/32113161
http://dx.doi.org/10.1016/j.ebiom.2020.102692