Cargando…

CBX4 transcriptionally suppresses KLF6 via interaction with HDAC1 to exert oncogenic activities in clear cell renal cell carcinoma

BACKGROUND: Dysregulation of polycomb chromobox (CBX) proteins that mediate epigenetic gene silencing contributes to the progression of human cancers. Yet their roles in clear cell renal cell carcinoma (ccRCC) remain to be explored. METHODS: The expression of CBX4 and its clinical significance were...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Nan, Niu, Gang, Pan, Ying-Hua, Pan, Wenwei, Zhang, Mei-Fang, Zhang, Chris Zhiyi, Shen, Huimin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044754/ https://www.ncbi.nlm.nih.gov/pubmed/32113161 http://dx.doi.org/10.1016/j.ebiom.2020.102692

Ejemplares similares

CBX1 Indicates Poor Outcomes and Exerts Oncogenic Activity in Hepatocellular Carcinoma()
por: Yang, Yu-Feng, et al.
Publicado: (2018)

Oncogenic role of the chromobox protein CBX7 in gastric cancer
por: Zhang, Xiao-Wei, et al.
Publicado: (2010)

CBX8 Suppresses Tumor Metastasis via Repressing Snail in Esophageal Squamous Cell Carcinoma
por: Wang, Gang, et al.
Publicado: (2017)

Targeting the Clear Cell Sarcoma Oncogenic Driver Fusion Gene EWSR1::ATF1 by HDAC Inhibition
por: Mae, Hirokazu, et al.
Publicado: (2023)

CBX8 exhibits oncogenic properties and serves as a prognostic factor in hepatocellular carcinoma
por: Tang, Bo, et al.
Publicado: (2019)

Single Nucleotide Polymorphisms of CBX4 and CBX7 Decrease the Risk of Hepatocellular Carcinoma
por: Tan, Chao, et al.
Publicado: (2019)

Phosphorylation of USP27X by GSK3β maintains the stability and oncogenic functions of CBX2
por: Xing, Yushu, et al.
Publicado: (2023)

Identification of the Prognostic Biomarkers CBX6 and CBX7 in Bladder Cancer
por: Li, Xinxin, et al.
Publicado: (2023)

Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role
por: Clermont, P-L, et al.
Publicado: (2014)

CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity
por: Chen, Jiasheng, et al.
Publicado: (2023)

HDAC1 and Klf4 interplay critically regulates human myeloid leukemia cell proliferation
por: Huang, Y, et al.
Publicado: (2014)

MicroRNA-455 suppresses the oncogenic function of HDAC2 in human colorectal cancer
por: Mao, Q.D., et al.
Publicado: (2017)

miR‑149‑3p suppresses the proliferation and metastasis of glioma cells by targeting the CBX2/Wnt/β‑catenin pathway
por: Wang, Yanjun, et al.
Publicado: (2023)

The HDAC inhibitor SAHA regulates CBX2 stability via a SUMO-triggered ubiquitin-mediated pathway in leukemia
por: Di Costanzo, Antonella, et al.
Publicado: (2018)

KLF5 inhibits STAT3 activity and tumor metastasis in prostate cancer by suppressing IGF1 transcription cooperatively with HDAC1
por: Ma, Jian-Bin, et al.
Publicado: (2020)

Discovery of BRAF/HDAC Dual Inhibitors Suppressing Proliferation of Human Colorectal Cancer Cells
por: Li, Yingjun, et al.
Publicado: (2022)

SPAG5 interacts with CEP55 and exerts oncogenic activities via PI3K/AKT pathway in hepatocellular carcinoma
por: Yang, Yu-Feng, et al.
Publicado: (2018)

Platelet releasates promote the proliferation of hepatocellular carcinoma cells by suppressing the expression of KLF6
por: He, Ao-Di, et al.
Publicado: (2017)

Long noncoding RNA lnc-DILC stabilizes PTEN and suppresses clear cell renal cell carcinoma progression
por: Zhang, Han, et al.
Publicado: (2019)

A novel approach to modelling transcriptional heterogeneity identifies the oncogene candidate CBX2 in invasive breast carcinoma
por: Piqué, Daniel G., et al.
Publicado: (2019)

WDR54 exerts oncogenic roles in T‐cell acute lymphoblastic leukemia
por: Li, Huan, et al.
Publicado: (2023)

Cbx7 promotes the generation of induced pluripotent stem cells
por: Wang, Chie-Hong, et al.
Publicado: (2023)

Hyperphosphorylated PTEN exerts oncogenic properties
por: van Ree, Janine H., et al.
Publicado: (2023)

CBX7 suppresses cell proliferation, migration, and invasion through the inhibition of PTEN/Akt signaling in pancreatic cancer
por: Ni, Sujie, et al.
Publicado: (2016)

PDE4B Induces Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Is Transcriptionally Suppressed by CBX7
por: Huang, Zhengnan, et al.
Publicado: (2021)

CBX4-dependent regulation of HDAC3 nuclear translocation reduces Bmp2-induced osteoblastic differentiation and calcification in adamantinomatous craniopharyngioma
por: Yan, Xiaorong, et al.
Publicado: (2022)

lncRNA KLF3-AS1 Suppresses Cell Migration and Invasion in ESCC by Impairing miR-185-5p-Targeted KLF3 Inhibition
por: Liu, Jun-Qi, et al.
Publicado: (2020)

Structure–Activity Relationships of Cbx7 Inhibitors, Including Selectivity Studies against Other Cbx Proteins
por: Simhadri, Chakravarthi, et al.
Publicado: (2016)

HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma
por: Ramakrishnan, Swathi, et al.
Publicado: (2016)

Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancer
por: Tang, Jianjun, et al.
Publicado: (2014)

Identification of miR-758-3p as Potential Modulator of CBX5 Expression in Gastric Cancer
por: Guo, Jinxing, et al.
Publicado: (2018)

Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells
por: Xu, Yanni, et al.
Publicado: (2017)

Ceruloplasmin overexpression is associated with oncogenic pathways and poorer survival rates in clear‐cell renal cell carcinoma
por: Zhang, Yong, et al.
Publicado: (2021)

miR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene
por: Forzati, Floriana, et al.
Publicado: (2017)

Multiomics integrative analysis reveals antagonistic roles of CBX2 and CBX7 in metabolic reprogramming of breast cancer
por: Iqbal, Mohammad Askandar, et al.
Publicado: (2021)

Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma
por: Petrozza, Vincenzo, et al.
Publicado: (2015)

MicroRNA-206 exerts anti-oncogenic functions in esophageal squamous cell carcinoma by suppressing the c-Met/AKT/mTOR pathway
por: Zhang, Jin, et al.
Publicado: (2019)

KLF8 knockdown suppresses proliferation and invasion in human osteosarcoma cells
por: LIN, FENG, et al.
Publicado: (2014)

Klf5 suppresses ERK signaling in mouse pluripotent stem cells
por: Azami, Takuya, et al.
Publicado: (2018)

CDCA2 acts as an oncogene and induces proliferation of clear cell renal cell carcinoma cells
por: Li, Fang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bc9q8hqoesu4jae7ivgdkscigd