Antiviral therapy: Valacyclovir Treatment of Alzheimer’s Disease (VALAD) Trial: protocol for a randomised, double-blind, placebo-controlled, treatment trial

INTRODUCTION: After infection, herpes simplex virus-1 (HSV1) becomes latent in the trigeminal ganglion and can enter the brain via retrograde axonal transport. Recurrent reactivation of HSV1 may lead to neurodegeneration and Alzheimer’s disease (AD) pathology. HSV1 (oral herpes) and HSV2 (genital he...

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Detalles Bibliográficos
Autores principales: Devanand, D P, Andrews, Howard, Kreisl, William C, Razlighi, Qolamreza, Gershon, Anne, Stern, Yaakov, Mintz, Akiva, Wisniewski, Thomas, Acosta, Edward, Pollina, Julianna, Katsikoumbas, Mariasofia, Bell, Karen L, Pelton, Gregory H, Deliyannides, Deborah, Prasad, K M, Huey, Edward D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045215/
https://www.ncbi.nlm.nih.gov/pubmed/32034019
http://dx.doi.org/10.1136/bmjopen-2019-032112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045215/
https://www.ncbi.nlm.nih.gov/pubmed/32034019
http://dx.doi.org/10.1136/bmjopen-2019-032112

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