Cargando…

Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84

BACKGROUND: Medium-chain fatty acids and their 3-hydroxy derivatives are metabolites endogenously produced in humans, food-derived or originating from bacteria. They activate G protein-coupled receptors, including GPR84 and HCA(3), which regulate metabolism and immune functions. Although both recept...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peters, Anna, Rabe, Philipp, Krumbholz, Petra, Kalwa, Hermann, Kraft, Robert, Schöneberg, Torsten, Stäubert, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045412/ https://www.ncbi.nlm.nih.gov/pubmed/32102673 http://dx.doi.org/10.1186/s12964-020-0516-2

Ejemplares similares

Combining metabolic phenotype determination with metabolomics and transcriptional analyses to reveal pathways regulated by hydroxycarboxylic acid receptor 2
por: Rabe, Philipp, et al.
Publicado: (2022)

Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3
por: Peters, Anna, et al.
Publicado: (2019)

Correction: Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3
por: Peters, Anna, et al.
Publicado: (2019)

Protocol to characterize G(i/o) and G(s) protein-coupled receptors in transiently transfected cells using ELISA and cAMP measurements
por: Liebing, Aenne-Dorothea, et al.
Publicado: (2023)

Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism
por: Stäubert, Claudia, et al.
Publicado: (2015)

Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules
por: Schulze, Amadeus Samuel, et al.
Publicado: (2022)

Exploring G Protein-Coupled Receptor Signaling in Primary Pancreatic Islets
por: Röthe, Juliane, et al.
Publicado: (2020)

Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133)
por: Fischer, Liane, et al.
Publicado: (2016)

Production of Hydroxycarboxylic Acid Receptor 3 (HCA(3)) Ligands by Bifidobacterium
por: Sakurai, Takuma, et al.
Publicado: (2021)

Therapeutic validation of an orphan G protein‐coupled receptor: The case of GPR84
por: Marsango, Sara, et al.
Publicado: (2020)

Stachel-mediated activation of adhesion G protein-coupled receptors: insights from cryo-EM studies
por: Liebscher, Ines, et al.
Publicado: (2022)

Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding
por: Suzuki, Shota, et al.
Publicado: (2023)

Structural and Functional Evolution of the Trace Amine-Associated Receptors TAAR3, TAAR4 and TAAR5 in Primates
por: Stäubert, Claudia, et al.
Publicado: (2010)

Investigating the Structure–Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists
por: Mahindra, Amit, et al.
Publicado: (2022)

Hydroxycarboxylic Acid Receptor 1 and Neuroprotection in a Mouse Model of Cerebral Ischemia-Reperfusion
por: Buscemi, Lara, et al.
Publicado: (2021)

Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2
por: Cheng, Lin, et al.
Publicado: (2023)

Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2
por: Pan, Xin, et al.
Publicado: (2023)

Genetic basis of functional variability in adhesion G protein-coupled receptors
por: Knierim, Alexander Bernd, et al.
Publicado: (2019)

Identifying G protein-coupled receptors involved in adipose tissue function using the innovative RNA-seq database FATTLAS
por: Kaczmarek, Isabell, et al.
Publicado: (2023)

6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84)
por: Pillaiyar, Thanigaimalai, et al.
Publicado: (2018)

Agonists for G-protein-coupled receptor 84 (GPR84) alter cellular morphology and motility but do not induce pro-inflammatory responses in microglia
por: Wei, Li, et al.
Publicado: (2017)

Rare and potentially pathogenic variants in hydroxycarboxylic acid receptor genes identified in breast cancer cases
por: McGuire Sams, Cierla, et al.
Publicado: (2021)

Prevention of Cell Death by Activation of Hydroxycarboxylic Acid Receptor 1 (GPR81) in Retinal Explants
por: Vohra, Rupali, et al.
Publicado: (2022)

The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation
por: Wannick, Melanie, et al.
Publicado: (2018)

The N Terminus of Adhesion G Protein–Coupled Receptor GPR126/ADGRG6 as Allosteric Force Integrator
por: Mitgau, Jakob, et al.
Publicado: (2022)

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84
por: Mahmud, Zobaer Al, et al.
Publicado: (2017)

Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response
por: Parodi, Benedetta, et al.
Publicado: (2021)

Elevated Circulating Lactate Levels and Widespread Expression of Its Cognate Receptor, Hydroxycarboxylic Acid Receptor 1 (HCAR1), in Ovarian Cancer
por: Kerslake, Rachel, et al.
Publicado: (2022)

The dimerized pentraxin-like domain of the adhesion G protein–coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces
por: Kieslich, Björn, et al.
Publicado: (2023)

The repertoire of Adhesion G protein-coupled receptors in adipocytes and their functional relevance
por: Suchý, Tomáš, et al.
Publicado: (2020)

Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA(2))
por: Markovics, Arnold, et al.
Publicado: (2019)

Evaluation of Hydroxycarboxylic Acid Receptor 1 (HCAR1) as a Building Block for Genetically Encoded Extracellular Lactate Biosensors
por: Wellbourne-Wood, Joel, et al.
Publicado: (2022)

Structural Insights into Ligand—Receptor Interactions Involved in Biased Agonism of G-Protein Coupled Receptors
por: Jóźwiak, Krzysztof, et al.
Publicado: (2021)

Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor
por: Reyes-Alcaraz, Arfaxad, et al.
Publicado: (2018)

Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives
por: Ren, Qun, et al.
Publicado: (2010)

Chiroptical activity of hydroxycarboxylic acids with implications for the origin of biological homochirality
por: Bocková, Jana, et al.
Publicado: (2021)

The GPS Motif Is a Molecular Switch for Bimodal Activities of Adhesion Class G Protein-Coupled Receptors
por: Prömel, Simone, et al.
Publicado: (2012)

The GPS Motif Is a Molecular Switch for Bimodal Activities of Adhesion Class G Protein-Coupled Receptors
por: Prömel, Simone, et al.
Publicado: (2012)

A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors
por: Gundry, Jaimee, et al.
Publicado: (2017)

Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor
por: Bridge, L.J., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jcc19qa4lmg75uu59sod6pcfdt