m(6)A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC

BACKGROUND: The importance of mRNA methylation erased by ALKBH5 in mRNA biogenesis, decay, and translation control is an emerging research focus. Ectopically activated YAP is associated with the development of many human cancers. However, the mechanism whereby ALKBH5 regulates YAP expression and act...

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Detalles Bibliográficos
Autores principales: Jin, Dan, Guo, Jiwei, Wu, Yan, Yang, Lijuan, Wang, Xiaohong, Du, Jing, Dai, Juanjuan, Chen, Weiwei, Gong, Kaikai, Miao, Shuang, Li, Xuelin, Sun, Hongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045432/
https://www.ncbi.nlm.nih.gov/pubmed/32106857
http://dx.doi.org/10.1186/s12943-020-01161-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045432/
https://www.ncbi.nlm.nih.gov/pubmed/32106857
http://dx.doi.org/10.1186/s12943-020-01161-1

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