Cargando…

Improved Synthesis and Isolation of Bedaquiline

[Image: see text] Bedaquiline (BDQ) is the most critical pharmaceutical in the world for treating multidrug-resistant Mycobacterium tuberculosis. Despite it being highly effective, BDQ asymmetric synthesis remains a challenge. Herein, the influence of chiral bases, namely, bis(1-phenylethyl)amine, b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lubanyana, Hlengekile, Arvidsson, Per I., Govender, Thavendran, Kruger, Hendrik G., Naicker, Tricia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045498/ https://www.ncbi.nlm.nih.gov/pubmed/32118176 http://dx.doi.org/10.1021/acsomega.9b04037

Ejemplares similares

Correction to “Improved Synthesis and Isolation of Bedaquiline”
por: Lubanyana, Hlengekile, et al.
Publicado: (2020)

Bedaquiline has potential for targeting tuberculosis reservoirs in the central nervous system
por: Pamreddy, Annapurna, et al.
Publicado: (2018)

6,7-Dimethoxy-3-methoxycarbonyl-1-(2-methoxyphenyl)-3,4-dihydroisoquinoline 2-oxide
por: Naicker, Tricia, et al.
Publicado: (2011)

(1S,3S)-Methyl 6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
por: Naicker, Tricia, et al.
Publicado: (2011)

(1S,3S)-Methyl 2-benzyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
por: Naicker, Tricia, et al.
Publicado: (2011)

(S)-2-Benzyl-N-(2,6-diisopropylphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
por: Naicker, Tricia, et al.
Publicado: (2011)

{(1R,3S)-2-Benzyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl}diphenylmethanol
por: Naicker, Tricia, et al.
Publicado: (2010)

Methyl 1-cyclohexyl-6,7-dimethoxy-3,4-dihydroisoquinoline-3-carboxylate
por: Naicker, Tricia, et al.
Publicado: (2011)

(1R,3S)-Methyl 6,7-dimethoxy-1-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
por: Naicker, Tricia, et al.
Publicado: (2010)

(3S)-2-Benzyl-3-carboxy-1,2,3,4-tetrahydroisoquinolinium chloride monohydrate
por: Naicker, Tricia, et al.
Publicado: (2010)

(S)-N-Benzyl-2-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
por: Naicker, Tricia, et al.
Publicado: (2010)

Synthesis of novel 1,2,4-thiadiazinane 1,1-dioxides via three component SuFEx type reaction
por: Khumalo, Mzilikazi F., et al.
Publicado: (2018)

Benzyl 5-hydroxy-4-oxapentacyclo[5.4.1.0(2,6).0(3,10).0(8,11)]dodecane-3-carboxylate
por: Karpoormath, Rajshekhar, et al.
Publicado: (2011)

(1R,3S)-Methyl 2-benzyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
por: Naicker, Tricia, et al.
Publicado: (2009)

(1R,3S)-N-Benzhydryl-2-benzyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carbothioamide
por: Naicker, Tricia, et al.
Publicado: (2011)

(S)-Methyl 3-(3,4-dimethoxyphenyl)-2-[2-(diphenylphosphanyl)benzamido]propanoate
por: Naicker, Tricia, et al.
Publicado: (2011)

(S)-Methyl 2-benzamido-3-(3,4-dimethoxyphenyl)propanoate
por: Naicker, Tricia, et al.
Publicado: (2011)

Synthesis and biological evaluation of novel β-lactam-metallo β-lactamase inhibitors
por: Shungube, Mbongeni, et al.
Publicado: (2023)

Mass Spectrometry Imaging Demonstrates the Regional Brain Distribution Patterns of Three First-Line Antiretroviral Drugs
por: Ntshangase, Sphamandla, et al.
Publicado: (2019)

(S)-Benzyl 3-phenylcarbamoyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate
por: Naicker, Tricia, et al.
Publicado: (2012)

Antibiotic‐Derived Radiotracers for Positron Emission Tomography: Nuclear or “Unclear” Infection Imaging?
por: Gouws, Arno Christiaan, et al.
Publicado: (2022)

A novel and more efficient biosynthesis approach for human insulin production in Escherichia coli (E. coli)
por: Govender, Kamini, et al.
Publicado: (2020)

Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease
por: Maseko, Sibusiso, et al.
Publicado: (2019)

Mass Spectrometric Imaging of the Brain Demonstrates the Regional Displacement of 6-Monoacetylmorphine by Naloxone
por: Teklezgi, Belin G., et al.
Publicado: (2020)

In Vitro and In Vivo Development of a β-Lactam-Metallo-β-Lactamase Inhibitor: Targeting Carbapenem-Resistant Enterobacterales
por: Peters, Byron K., et al.
Publicado: (2023)

Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors
por: Reddy, Nakita, et al.
Publicado: (2023)

Diastereoselectivity is in the Details: Minor Changes Yield Major Improvements to the Synthesis of Bedaquiline
por: Mear, Sarah Jane, et al.
Publicado: (2022)

tert-Butyl N-[(11-exo-benzyloxycarbonyl-8-oxopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane-11-endo-yloxy)carbonylmethyl]carbamate
por: Karpoormath, Rajshekhar, et al.
Publicado: (2010)

N,N′-[(8-endo,11-endo-Dihydroxypentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane-8,11-diyl)bis(methylenecarbonyl)]di-l-phenylalanine
por: Karpoormath, Rajshekhar, et al.
Publicado: (2010)

endo-11-(Dibenzylamino)tetracyclo[5.4.0.0(3,10).0(5,9)]undecane-8-one
por: Karpoormath, Rajshekhar, et al.
Publicado: (2011)

N-Benzyl-5-(dimethylamino)naphthalene-1-sulfonamide
por: Bhatt, Pralav, et al.
Publicado: (2011)

N-(2-Hydroxyethyl)-N-(tricyclo[3.3.1.1(3,7)]dec-2-yl)benzamide
por: Boyle, Grant A., et al.
Publicado: (2008)

2-(Tricyclo[3.3.1.1(3,7)]dec-2-ylamino)ethanol hemihydrate
por: Boyle, Grant A., et al.
Publicado: (2008)

(S)-4-tert-Butyl-2-(1,2,3,4-tetrahydroisoquinolin-3-yl)-1,3-thiazole
por: Pawar, Sunayna, et al.
Publicado: (2012)

N-(Adamantan-1-yl)-2-chloroacetamide
por: Onajole, Oluseye K., et al.
Publicado: (2011)

(R)-4-Phenyl-2-[(S)-1,2,3,4-tetrahydroisoquinolin-3-yl]-4,5-dihydro-1,3-oxazole
por: Chakka, Sai K., et al.
Publicado: (2010)

8-(Biphenyl-4-yl)-8-hydroxypentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecan-11-one ethylene ketal
por: Boyle, Grant A., et al.
Publicado: (2007)

Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline
por: Robey, Juliana M. S., et al.
Publicado: (2023)

Maleate salts of bedaquiline
por: Zeller, Matthias, et al.
Publicado: (2021)

(S)-4-Phenyl-2-(1,2,3,4-tetrahydroisoquinolin-3-yl)-1,3-thiazole
por: Pawar, Sunayna, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_9i6t1mlou1rcdqu97ggls8sda4