A comparison of hepato-cellular in vitro platforms to study CYP3A4 induction

In vitro studies of drug toxicity and drug-drug interactions are crucial for drug development efforts. Currently, the utilization of primary human hepatocytes (PHHs) is the de facto standard for this purpose, due to their functional xenobiotic response and drug metabolizing CYP450 enzyme metabolism....

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Detalles Bibliográficos
Autores principales: Bulutoglu, Beyza, Rey-Bedón, Camilo, Mert, Safak, Tian, Lipeng, Jang, Yoon-Young, Yarmush, Martin L., Usta, O. Berk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046200/
https://www.ncbi.nlm.nih.gov/pubmed/32106230
http://dx.doi.org/10.1371/journal.pone.0229106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046200/
https://www.ncbi.nlm.nih.gov/pubmed/32106230
http://dx.doi.org/10.1371/journal.pone.0229106

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