Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance

The enantiomers of many chiral drugs not only exhibit different pharmacological effects in regard to targets that dictate therapeutic and toxic effects, but are also handled differently in the body due to pharmacokinetic effects. We investigated the pharmacokinetics of the enantiomers of N-acetyl-le...

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Detalles Bibliográficos
Autores principales: Churchill, Grant C., Strupp, Michael, Galione, Antony, Platt, Frances M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046201/
https://www.ncbi.nlm.nih.gov/pubmed/32108176
http://dx.doi.org/10.1371/journal.pone.0229585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046201/
https://www.ncbi.nlm.nih.gov/pubmed/32108176
http://dx.doi.org/10.1371/journal.pone.0229585

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