Adaptive phenotypic modulations lead to therapy resistance in chronic myeloid leukemia cells

Tyrosine kinase inhibitor (TKI) resistance is a major problem in chronic myeloid leukemia (CML). We generated a TKI-resistant K562 sub-population, K562-IR, under selective imatinib-mesylate pressure. K562-IR cells are CD34(-)/CD38(-), BCR-Abl-independent, proliferate slowly, highly adherent and form...

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Detalles Bibliográficos
Autores principales: Baykal-Köse, Seda, Acikgoz, Eda, Yavuz, Ahmet Sinan, Gönül Geyik, Öykü, Ateş, Halil, Sezerman, Osman Uğur, Özsan, Güner Hayri, Yüce, Zeynep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046262/
https://www.ncbi.nlm.nih.gov/pubmed/32106243
http://dx.doi.org/10.1371/journal.pone.0229104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046262/
https://www.ncbi.nlm.nih.gov/pubmed/32106243
http://dx.doi.org/10.1371/journal.pone.0229104

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