Blockade of JAK2 protects mice against hypoxia‐induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation

OBJECTIVES: Hypoxia is an important risk factor for pulmonary arterial remodelling in pulmonary arterial hypertension (PAH), and the Janus kinase 2 (JAK2) is believed to be involved in this process. In the present report, we aimed to investigate the role of JAK2 in vascular smooth muscle cells durin...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Lei, Wang, Yi, Wu, Guorao, Rao, Lizong, Wei, Yanqiu, Yue, Huihui, Yuan, Ting, Yang, Ping, Xiong, Fei, Zhang, Shu, Zhou, Qing, Chen, Zhishui, Li, Jinxiu, Mo, Bi‐Wen, Zhang, Huilan, Xiong, Weining, Wang, Cong‐Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046303/
https://www.ncbi.nlm.nih.gov/pubmed/31943454
http://dx.doi.org/10.1111/cpr.12742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046303/
https://www.ncbi.nlm.nih.gov/pubmed/31943454
http://dx.doi.org/10.1111/cpr.12742

Ejemplares similares