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High-dose pharmaceutical grade biotin (MD1003) in amyotrophic lateral sclerosis: A pilot study

BACKGROUND: Oligodendrocytes (OGs) provide metabolic support to motor neurons (MNs) and are implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). MD1003, or high-dose Pharmaceutical grade Biotin (hdPB), may improve disability in progressive multiple sclerosis patients via augment...

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Detalles Bibliográficos
Autores principales: Juntas-Morales, Raul, Pageot, Nicolas, Bendarraz, Abdelkarim, Alphandéry, Sébastien, Sedel, Frédéric, Seigle, Stéphanie, Camu, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046518/
https://www.ncbi.nlm.nih.gov/pubmed/32140672
http://dx.doi.org/10.1016/j.eclinm.2019.100254