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High-dose pharmaceutical grade biotin (MD1003) in amyotrophic lateral sclerosis: A pilot study
BACKGROUND: Oligodendrocytes (OGs) provide metabolic support to motor neurons (MNs) and are implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). MD1003, or high-dose Pharmaceutical grade Biotin (hdPB), may improve disability in progressive multiple sclerosis patients via augment...
Autores principales: | Juntas-Morales, Raul, Pageot, Nicolas, Bendarraz, Abdelkarim, Alphandéry, Sébastien, Sedel, Frédéric, Seigle, Stéphanie, Camu, William |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046518/ https://www.ncbi.nlm.nih.gov/pubmed/32140672 http://dx.doi.org/10.1016/j.eclinm.2019.100254 |
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