Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability

Can antimicrobial activity and peptide stability of alpha-helical peptides be increased by making them into dimers and macrocycles? Here, we explore that concept by using KR-12 as the starting point for peptide engineering. KR-12 has previously been determined as the minimalized antimicrobial fragme...

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Detalles Bibliográficos
Autores principales: Gunasekera, Sunithi, Muhammad, Taj, Strömstedt, Adam A., Rosengren, K. Johan, Göransson, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046553/
https://www.ncbi.nlm.nih.gov/pubmed/32153522
http://dx.doi.org/10.3389/fmicb.2020.00168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046553/
https://www.ncbi.nlm.nih.gov/pubmed/32153522
http://dx.doi.org/10.3389/fmicb.2020.00168

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