A microparticulate based formulation to protect therapeutic enzymes from proteolytic digestion: phenylalanine ammonia lyase as case study

Phenylketonuria is a genetic disorder affecting the metabolism of phenylalanine (phe) due to a deficiency in the enzyme phenylalanine hydroxylase. This disorder is characterized by an elevated phe blood level, which can lead to severe intellectual disabilities in newborns. The current strategy to pr...

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Detalles Bibliográficos
Autores principales: Pereira de Sousa, Irene, Gourmel, Charlotte, Berkovska, Olena, Burger, Michael, Leroux, Jean-Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046617/
https://www.ncbi.nlm.nih.gov/pubmed/32107425
http://dx.doi.org/10.1038/s41598-020-60463-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046617/
https://www.ncbi.nlm.nih.gov/pubmed/32107425
http://dx.doi.org/10.1038/s41598-020-60463-y

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