Hypercholesterolemia Accelerates the Aging Phenotypes of Hematopoietic Stem Cells by a Tet1-Dependent Pathway

Hypercholesterolemia accelerates the phenotypes of aging in hematopoietic stem cells (HSCs). As yet, little is known about the underlying mechanism. We found that hypercholesterolemia downregulates Ten eleven translocation 1 (Tet1) in HSCs. The total HSC population was increased, while the long-term...

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Detalles Bibliográficos
Autores principales: Tie, Guodong, Yan, Jinglian, Khair, Lyne, Tutto, Amanda, Messina, Louis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046636/
https://www.ncbi.nlm.nih.gov/pubmed/32107419
http://dx.doi.org/10.1038/s41598-020-60403-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046636/
https://www.ncbi.nlm.nih.gov/pubmed/32107419
http://dx.doi.org/10.1038/s41598-020-60403-w

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