Endothelin-1 Mediated Decrease in Mitochondrial Gene Expression and Bioenergetics Contribute to Neurodegeneration of Retinal Ganglion Cells

Endothelin-1 (ET-1) is a vasoactive peptide that is elevated in aqueous humor as well as circulation of primary open angle glaucoma (POAG) patients. ET-1 has been shown to promote degeneration of optic nerve axons and apoptosis of retinal ganglion cells (RGCs), however, the precise mechanisms are st...

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Detalles Bibliográficos
Autores principales: Chaphalkar, Renuka M., Stankowska, Dorota L., He, Shaoqing, Kodati, Bindu, Phillips, Nicole, Prah, Jude, Yang, Shaohua, Krishnamoorthy, Raghu R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046667/
https://www.ncbi.nlm.nih.gov/pubmed/32107448
http://dx.doi.org/10.1038/s41598-020-60558-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046667/
https://www.ncbi.nlm.nih.gov/pubmed/32107448
http://dx.doi.org/10.1038/s41598-020-60558-6

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